Protective Effect of Quinine on Chemical Kindling and Passive Avoidance Test in Rats

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چکیده

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Protective Effect of Quinine on Chemical Kindling and Passive Avoidance Test in Rats

BACKGROUND In humans, convulsive diseases such as temporal lobe epilepsy are usually accompanied by learning and memory impairments. In recent years, the role of gap junction channels as an important target of antiepileptic drugs has been studied and discussed. Quinine, as a gap junction blocker of connexin 36, can abolish ictal epileptiform activity in brain slices. OBJECTIVES The role of qu...

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Effect of Morphine on Passive Avoidance Memory in Cholestatic Rats

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Low Frequency Stimulation Reverses the Kindling-Induced Impairment of Learning and Memory in the Rat Passive-avoidance Test

Introduction: The life quality of patients with epileptic seizures is highly affected by cognitive deficits. Low Frequency Stimulation (LFS) is a novel approach for the treatment of pharmacoresistant epilepsy. The main goal of this research is investigating the possible effect of LFS on seizure-induced cognitive dysfunction.  Methods: To this end, the kindled animal were prepared via CA1 ...

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The Effect of Ginkgo on Baclofen Induced Amnesia using Passive Avoidance Learning and Memory in Rats

Background & Objective: Ginkgo biloba is an herbal medicine that has a positive effect on improving memory. It prevents oxidative damage in mitochondria and cell death in a variety of Neuropathies. Besides, baclofen is prescribed for its analgesic and anti-inflammatory effects but has negative impact on memory. The objective of this study is to investigate the interaction of ginkgo with GABA b ...

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ژورنال

عنوان ژورنال: Iranian Red Crescent Medical Journal

سال: 2016

ISSN: 2074-1804,2074-1812

DOI: 10.5812/ircmj.25490